Fang, Bo
Graduate student
Email: fangbo@mail.ustc.edu.cn

Autoinducer-2 £šAI-2£© is a signal molecule produced by LuxS and involved in quorum-sensing system in numerous bacteria. Although the receptor of AI-2 has been characterized in some Gram-negative bacteria, its receptor in Gram-positive bacteria hasn¡¯t been identified yet. My research focuses on the identification of the potential AI-2 receptor and the relative regulatory mechanisms in Staphylococcus aureus.


Guan, Jing
PhD Student
Email: guanjing@mail.ustc.edu.cn

In prokaryotes, CRISPR arrays and Cas proteins constitute a defence system against invading bacteriophages and plasmids. We have identified a few Staphylococcus aureus clinical strains with the type III CRISPR-Cas system and demonstrated their immunity. I am especially interested in how the CRISPR-Cas system in these clinical strains modulates genome stability and flexibility. 


Gul Habib
PhD Student
Email: gulhabib@mail.ustc.edu.cn

The phenotypic variants of regular cells that form stochastically in microbial populations, highly tolerant to antibiotics and largely responsible for recalcitrance of chronic infections are persister cells. My research focuses on the developmental strategies to tackle Staphylococcus aureus persister cells through genotypic modelling of persister cells using proteome analysis, cell sorting in combination with microfluidics technology.


Jin, Zeyu
PhD Student
Email: jinzeyu@mail.ustc.edu.cn

 

Staphylococcus aureus is one of the most detrimental pathogens with some genes whose functions still remain unknown. My research focuses on the identification and functional analysis of novel virulence factors using Saccharomyces cerevisiae as a eukaryotic host model.


Liu, Banghui
Graduate Student
Email: lbh920@mail.ustc.edu.cn

 

Methicillin-resistant Staphylococcus aureus (MRSA) strains are considered Staphylococcus aureus isolates with oxacillin minimum inhibitory concentration (MIC) of ≥4 mg/L or harboring the mecA gene. However, the oxacillin-susceptible, mecA-positive S. aureus isolates (commonly called OS-MRSA) are often detected worldwide and the underlying mechanisms conferring the OS-MRSA phenotype are largely obscure. My research focuses on the detailed molecular mechanism regulating oxacillin-susceptible phenotype in mecA-positive S. aureus.


Liu, Dehua
Graduate student
Email: ldh621@mail.ustc.edu.cn

Toxin-antitoxin systems are involved in bacterial survival under stress conditions. They are composed of stable toxin that can harm the host cell and its cognate labile antitoxin that protects the cell from the toxin¡¯s deleterious effect. My research project aims to elucidate the biological function and molecular mechanisms of toxin-antitoxin systems in Staphylococcus aureus.


Shu, Xueqin
Graduate Student
Email: shirleys@mail.ustc.edu.cn

Methicillin-resistant Staphylococcus aureus (MRSA) is a human and animal pathogen that can cause a broad spectrum of infections diseases. MRSA strains are hard to treat due to their resistance to almost the entire family of β-lactam antibiotics. The molecular mechanisms regulating the emergence and spread of antibiotic resistance in MRSA strains remain largely unknown. My research focuses on the elucidation of environmental stimuli and molecular basis of drug resistance.


Wang, Wanying
Graduate Student
Email: wyw927@mail.ustc.edu.cn

The CRISPR-Cas system in prokaryote can provide adaptive immunity against invading nucleic acids. Our RNA-seq data have revealed that Staphylococcus aureus type III CRISPR system can modulate the expression of numerous genes, such as metabolism and virulence genes. My research focuses on the molecular mechanism by which the CRISPR-Cas system regulates virulence in S. aureus clinical strains.


Wen, Wen
PhD Student
Email: mosww@mail.ustc.edu.cn

Stable fluorescent protein markers provide an intuitive, non-destructive technique for the study of the biofilm formation as well as the dynamic process of host infection in Staphylococcus aureus. By constructing and tracking fluorescent strains in the process of biofilm formation, cell and animal infection, we aim to provide novel strategies for the prevention and treatment of S. aureus infection.


Zhu, Jiade
PhD Student
Email: zjd6678@mail.ustc.edu.cn

Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci and the CRISPR-associated genes function together as a prokaryotic adaptive immune system, which provides protection against invading mobile genetic elements such as plasmids and phages. My research project concentrates on the function and molecular mechanism of CRISPR-Cas systems in Staphylococcus aureus.


Zhu, Qing
PhD Student
Email: zhuqq@mail.ustc.edu.cn

The CRISPR/Cas system in bacteria and archaea provides a sequence-based adaptive immunity against invader DNA/RNA. RNA-seq  and phenotypic analysis reveal that  Staphylococcus aureus type III CRISPR system modulates the expression of a spectrum of genes such as virulence and metabolism genes. I am interested in the regulatory mechanism of the CRISPR/Cas system involved in nitrite assimilation in Staphylococcus aureus clinical strains.