Fang, Bo
Graduate student
Email: fangbo@mail.ustc.edu.cn

Autoinducer-2 £šAI-2£© is a signal molecule produced by LuxS and involved in quorum-sensing system in numerous bacteria. Although the receptor of AI-2 has been characterized in some Gram-negative bacteria, its receptor in Gram-positive bacteria hasn¡¯t been identified yet. My research focuses on the identification of the potential AI-2 receptor and the relative regulatory mechanisms in Staphylococcus aureus.


Guan, Jing
PhD Student
Email: guanjing@mail.ustc.edu.cn

In prokaryotes, CRISPR arrays and Cas proteins constitute a defence system against invading bacteriophages and plasmids. We have identified a few Staphylococcus aureus clinical strains with the type III CRISPR-Cas system and demonstrated their immunity. I am especially interested in how the CRISPR-Cas system in these clinical strains modulates genome stability and flexibility. 


Liu, Banghui
Graduate Student
Email: lbh920@mail.ustc.edu.cn

 

Methicillin-resistant Staphylococcus aureus (MRSA) strains are considered Staphylococcus aureus isolates with oxacillin minimum inhibitory concentration (MIC) of ≥4 mg/L or harboring the mecA gene. However, the oxacillin-susceptible, mecA-positive S. aureus isolates (commonly called OS-MRSA) are often detected worldwide and the underlying mechanisms conferring the OS-MRSA phenotype are largely obscure. My research focuses on the detailed molecular mechanism regulating oxacillin-susceptible phenotype in mecA-positive S. aureus.


Liu, Dehua
Graduate student
Email: ldh621@mail.ustc.edu.cn

Toxin-antitoxin systems are involved in bacterial survival under stress conditions. They are composed of stable toxin that can harm the host cell and its cognate labile antitoxin that protects the cell from the toxin¡¯s deleterious effect. My research project aims to elucidate the biological function and molecular mechanisms of toxin-antitoxin systems in Staphylococcus aureus.


Li, Jingrong
Graduate student
Email: ljr1231@mail.ustc.edu.cn

Methylation is considered to be important for fine-tuning ribosome function. Most studies of rRNA methyltransferases are conducted in gram-negative bacteria. However, the functions of rRNA methyltransferases in gram-positive bacteria are unclear. My research focuses on the functions and molecular mechanisms of rRNA methyltransferases in Staphylococcus aureus.


Li, Tian
Graduate student
Email: motang@mail.ustc.edu.cn

Filamenting temperature-sensitive mutant Z (FtsZ) is a prokaryotic homologue to the eukaryotic protein tubulin, binds GTP and exhibits GTPase activity. During bacterial cell division, FtsZ is the first protein to move to the division site, and recruits other cell division proteins to the septum to produce a new cell wall between the dividing cells. I am interested in the DNA binding property of FtsZ and its function to guide the migration of chromosomes in Staphylococcus aureus.


Shu, Xueqin
Graduate Student
Email: shirleys@mail.ustc.edu.cn

Methicillin-resistant Staphylococcus aureus (MRSA) is a human and animal pathogen that can cause a broad spectrum of infections diseases. MRSA strains are hard to treat due to their resistance to almost the entire family of β-lactam antibiotics. The molecular mechanisms regulating the emergence and spread of antibiotic resistance in MRSA strains remain largely unknown. My research focuses on the elucidation of environmental stimuli and molecular basis of drug resistance.


Wang, Wanying
Graduate Student
Email: wyw927@mail.ustc.edu.cn

The CRISPR-Cas system in prokaryote can provide adaptive immunity against invading nucleic acids. Our RNA-seq data have revealed that Staphylococcus aureus type III CRISPR system can modulate the expression of numerous genes, such as metabolism and virulence genes. My research focuses on the molecular mechanism by which the CRISPR-Cas system regulates virulence in S. aureus clinical strains.


Zhu, Jiade
PhD Student
Email: zjd6678@mail.ustc.edu.cn

Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci and the CRISPR-associated genes function together as a prokaryotic adaptive immune system, which provides protection against invading mobile genetic elements such as plasmids and phages. My research project concentrates on the function and molecular mechanism of CRISPR-Cas systems in Staphylococcus aureus.


Zhu, Qing
PhD Student
Email: zhuqq@mail.ustc.edu.cn

The CRISPR/Cas system in bacteria and archaea provides a sequence-based adaptive immunity against invader DNA/RNA. RNA-seq  and phenotypic analysis reveal that  Staphylococcus aureus type III CRISPR system modulates the expression of a spectrum of genes such as virulence and metabolism genes. I am interested in the regulatory mechanism of the CRISPR/Cas system involved in nitrite assimilation in Staphylococcus aureus clinical strains.